Kenny Moore II is out for a third straight Colts game with an Achilles issue, while Alec Pierce clears concussion protocol. Indianapolis’ defensive front features Buckner, Ebukam and Stewart in non-injury designations, with Braden Smith and Charvarius Ward listed but not currently sidelined. On the Cardinals side, Kyler Murray is limited with a foot issue and Zay Jones is knee-questionable; Darius Robinson is out, and several others are limited or questionable, shaping a game with mixed fantasy upside depending on activation and target distribution.

For fantasy managers, Moore’s absence tightens Colts secondary depth; if Arizona’s passing attack is able to push through, Cardinal receivers could see elevated looks, especially if Murray returns to closer to full health. Cardinals’ limited players in the slot and on the edge could hint at opportunistic plays for savvy depth options, while Colt players with clear designations should be approached with caution until full clarity emerges.

Week 5 injury watch centers on Tyquan Lewis, who is questionable with an oblique after two limited practices. If Lewis sits, JT Tuimoloau steps into a larger edge role behind a rotation anchored by Laiatu Latu, Samson Ebukam, and Kwity Paye, with Latu handling interior pass rush on certain packages. Fantasy angles shift to Latu’s snap counts and the Colts’ pass rush depth against the Raiders, plus the impact of any fallback options on downs 3-4.

Inactive or not, the storm clouds around the Colts’ DE group could tilt the rotation toward Tuimoloau and increased interior pressure on passing downs. Raiders’ line protections will test the group, so fantasy managers should monitor final inactives and practice reports closely before kickoff.